Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin.
نویسندگان
چکیده
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
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ورودعنوان ژورنال:
- Organic letters
دوره 14 22 شماره
صفحات -
تاریخ انتشار 2012